Safeguarding America's Future and Environment Act or SAFE Act - Requires the President to establish an interagency Natural Resources Climate Change Adaptation Panel to: (1) adopt the National Fish, Wildlife, and Plants Climate Adaptation Strategy (released March 26, 2013) to protect, restore, and conserve natural resources so that such resources become more resilient, adapt to, and withstand the impacts of extreme weather and climate change; and (2) review and revise such strategy every four years.

Requires each agency represented on such panel to integrate the elements of such strategy that relate to conservation, restoration, and management of natural resources into agency plans, environmental reviews, and programs.

Requires the Secretary of the Interior to establish a National Climate Change and Wildlife Science Center within the United States Geological Survey (USGS) to assess and develop scientific information, tools, strategies, and techniques to be used to address the impacts of extreme weather and climate change on natural resources.

Requires the Secretary of Commerce and the Secretary of the Interior to establish a Science Advisory Board to advise such Panel on the state of the science regarding such impacts and strategies and mechanisms for natural resources adaptation.

Requires each agency represented on such panel to submit to the President a natural resources adaptation plan to address such impacts and implement the plan upon approval by the President.

Requires states, in order to be eligible to receive funding under this Act, to submit to the Secretary of the Interior and, as applicable, the Secretary of Commerce for review and approval a state natural resources adaptation plan that details efforts to address impacts of climate change on natural resources and coastal areas.