Red River National Wildlife Refuge Act - Directs the Secretary of the Interior to: (1) seek to acquire up to 50,000 acres of land, water, or interests (including permanent conservation easements or servitudes) within the boundaries of a selection area consisting of Caddo, Bossier, Red River, DeSoto, and Natchitoches Parishes, Louisiana; and (2) establish such lands, waters, and interests as the Red River National Wildlife Refuge at such time as the Secretary determines that sufficient property has been acquired to constitute an area that can be effectively managed as a national wildlife refuge for specified purposes, including to restore and preserve native Red River ecosystems, provide habitat for migratory birds, and maximize fisheries on the Red River and its tributaries, natural lakes, and man-made reservoirs.

Requires the Secretary to issue a management plan for the Refuge which includes provisions that provide for: (1) the planning and design of trails and access points; (2) the planning of wildlife and habitat restoration, including reforestation; and (3) permanent exhibits and facilities and regular educational programs throughout the Refuge.

Requires that the Secretary: (1) provide an opportunity for public participation in developing such plan; and (2) give special consideration to views by local public and private entities and individuals.

Directs the Secretary to construct, administer, and maintain within the Refuge, a wildlife interpretation and education center to promote environmental education and to provide an opportunity for the study and enjoyment of wildlife in its natural habitat.

Sets forth requirements for the designation of boundaries for the Refuge.

Declares that nothing in this Act shall be construed as prohibiting or preventing, and the Secretary shall not prohibit or prevent: (1) the continuation or development of commercial or recreational navigation on the Red River Waterway; (2) necessary construction, operation, or maintenance activities associated with the Red River Waterway project; (3) the construction, improvement, or expansion of public port or recreational facilities on such Waterway; or (4) the construction, improvement, or replacement of railroads or interstate highways within the selection area, or bridges that cross the Red River.

Authorizes appropriations.