High-Tech Port Security Act of 2003 - Instructs the Secretary of the Department of Homeland Security to prescribe regulations: (1) establishing certification standards and procedures for blast-resistant containers; and (2) prohibiting entry into the United States of any vessel carrying regulated containers after such regulations are prescribed unless they are all certified blast-resistant.

Directs the Secretary to: (1) establish standards for the certification of equipment designed to screen a container carried by a vessel entering the United States for radioactive and explosive materials before the container leaves the port; (2) take action to ensure that the twenty largest domestic ports (and any others determined highly vulnerable) have deployed such certified screening equipment; and (3) establish command and control centers at the twenty largest domestic ports.