Safe Motherhood Monitoring and Prevention Research Act of 1999 - Amends the Public Health Service Act to authorize the Secretary of Health and Human Services, acting through the Centers for Disease Control and Prevention (CDC), to: (1) establish and implement a national monitoring and surveillance program to identify and promote the investigation of deaths and severe complications that occur during pregnancy; (2) expand the Pregnancy Risk Assessment Monitoring System to provide surveillance and collect data in each of the 50 States; (3) expand the Maternal and Child Health Epidemiology Program to provide technical support, financial assistance, or the time-limited assignment of senior epidemiologists to maternal and child health programs in each of the 50 States.

Authorizes the Secretary, acting through the CDC, to expand research relating to: (1) encouraging preconception counseling; (2) identifying critical components of prenatal delivery and postpartum care, outreach and support services for pregnant women, and women who are at high risk for complications; (3) preventing preterm delivery, urinary tract infections, and unnecessary caesarean sections; (4) examining the higher rates of maternal mortality among African American women and the relationship between domestic violence and maternal complications and mortality; and (5) preventing substance abuse during and after pregnancy and infections that cause maternal and infant complications.

Authorizes the Secretary, acting through the CDC, to carry out activities to promote safe motherhood, including public education campaigns on healthy pregnancies, education programs for health care providers, and activities to promote community support for pregnant women.

Authorizes appropriations.