Promoting Innovations to 21st Century Careers Act - Authorizes the Director of the National Academic and Career Innovation Center to award certain planning, implementation, transitional, and supplemental grants to state pathways partnerships to carry out activities that will create and enhance educational and career pathways for high school students to postsecondary schools (including registered apprenticeship programs) and to 21st century careers, particularly in high skill, high demand industries.

Requires the state partnerships to be appointed by state governors and include representatives from educational, business, labor, workforce, and economic development entities in their respective states.

Establishes the National Academic and Career Innovation Center to: (1) support the efforts of the state partnerships and regional partnerships (which are to receive competitive implementation subgrants from state partnerships) to offer career pathways of proven effectiveness; (2) design and conduct performance evaluations of career pathways activities; and (3) administer, oversee, and evaluate all career pathways grants.